Endocrine Abstracts

Introduction: The N-formyl peptide receptor (FPR) family of G-protein-coupled receptors, originally identified to recognise N-formylated bacterial peptides, has in more recent times been shown to bind annexin-1 (ANXA1). ANXA1 is a signalling molecule well demonstrated to mediate two key glucocorticoid effects in the anterior pituitary: inhibition of ACTH release from corticotrophs and regulation of cell proliferation. Whilst previous RT-PCR studies have detec...